volume | PIER Journals

Abstract

Magnetic nanoparticles (MNPs) have been widely investigated as effective drug carriers for targeted tumor therapy. However, the successful application of this technology in the human body requires reliable imaging support. Magnetoacoustic Concentration Tomography of Magnetic Nanoparticles with Magnetic Induction (MACT-MI) is an electromagnetic-ultrasonic coupling imaging technique that holds great promise in improving imaging resolution and providing unique advantages for tumor monitoring and treatment. To evaluate the imaging feasibility of MACT-MI technology for targeted therapy of breast tumors, this study establishes a realistic breast model and takes into account the distribution of magnetic particles within the actual breast tissue environment. A concentration gradient model is introduced, and the finite element method is employed to solve the electromagnetic and sound fields. In addressing the research objective, the forward problem is investigated by analyzing the magnetic force and sound pressure distribution for various tumor sizes and locations, different breast tissues, and both benign and malignant tumors. The results obtained indicate that the magnetoacoustic signal emitted by magnetic particles facilitates accurate mapping of the size and location information of magnetic particles enveloping breast tumors, as well as distinguishing between benign and malignant tumors.

1. Kianfar, Ehsan, "Magnetic nanoparticles in targeted drug delivery: A review," Journal of Superconductivity and Novel Magnetism, Vol. 34, No. 7, 1709-1735, Jul. 2021.
doi:10.1007/s10948-021-05932-9

2. Li, Ziqi, Weimin Wan, Ziwei Bai, Bo Peng, Xi Wang, Liu Cui, Zhaoyun Liu, Kui Lin, Jian Yang, Jia Hao, and Fei Tian, "Construction of pH-responsive nanoplatform from stable magnetic nanoparticles for targeted drug delivery and intracellular imaging," Sensors and Actuators, B: Chemical, Vol. 375, 132869, Jan. 2023.
doi:10.1016/j.snb.2022.132869

3. Yang, Haiyan, Fujie Jiang, Liang Zhang, Lu Wang, Yong Luo, Ningshan Li, Yu Guo, Qi Wang, and Jianzhong Zou, "Multifunctional L-arginine-based magnetic nanoparticles for multiple-synergistic tumor therapy," Biomaterials Science, Vol. 9, No. 6, 2230-2243, Mar. 2021.
doi:10.1039/d0bm01932a

4. Taherian, A., N. Esfandiari, and S. Rouhani, "Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles," Cancer Nanotechnology, Vol. 12, No. 1, Dec. 2021.
doi:10.1186/s12645-021-00086-8

5. Harvell-Smith, Stanley, Le Duc Tung, and Nguyen Thi Kim Thanh, "Magnetic particle imaging: Tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality," Nanoscale, Vol. 14, No. 10, 3658-3697, Mar. 2022.
doi:10.1039/d1nr05670k

6. Park, Sang-Jin, Seung Ro Han, Yun Hee Kang, Eun-Jin Lee, Eu-Gene Kim, Hyobong Hong, Jae-Chan Jeong, Myung-Shin Lee, Seung-Hoon Lee, and Dae-Yong Song, "In vivo preclinical tumor-specific imaging of superparamagnetic iron oxide nanoparticles using magnetic particle imaging for cancer diagnosis," International Journal of Nanomedicine, Vol. 17, 3711-3722, 2022.
doi:10.2147/IJN.S372494

7. Senthilkumar, Neeharika, Preetam Kumar Sharma, Neeru Sood, and Nikhil Bhalla, "Designing magnetic nanoparticles for in vivo applications and understanding their fate inside human body," Coordination Chemistry Reviews, Vol. 445, 214082, Oct. 2021.
doi:10.1016/j.ccr.2021.214082

8. Lu, Chang, Linbo Han, Joanna Wang, Jiacheng Wan, Guosheng Song, and Jianghong Rao, "Engineering of magnetic nanoparticles as magnetic particle imaging tracers," Chemical Society Reviews, Vol. 50, No. 14, 8102-8146, Jul. 2021.
doi:10.1039/d0cs00260g

9. Shi, Xiaoyu, Guoqiang Liu, Xiaoheng Yan, and Yanhong Li, "Simulation research on magneto-acoustic concentration tomography of magnetic nanoparticles with magnetic induction," Computers in Biology and Medicine, Vol. 119, 103653, Apr. 2020.
doi:10.1016/j.compbiomed.2020.103653

10. Yan, Xiaoheng, Ye Pan, Weihua Chen, Zhengyang Xu, and Zhengxing Li, "Simulation research on the forward problem of magnetoacoustic concentration tomography for magnetic nanoparticles with magnetic induction in a saturation magnetization state," Journal of Physics D: Applied Physics, Vol. 54, No. 7, 075002, 2020.
doi:10.1088/1361-6463/abc27c

11. Arnold, Melina, Eileen Morgan, Harriet Rumgay, Allini Mafra, Deependra Singh, Mathieu Laversanne, Jerome Vignat, Julie R. Gralow, Fatima Cardoso, Sabine Siesling, and Isabelle Soerjomataram, "Current and future burden of breast cancer: Global statistics for 2020 and 2040," Breast, Vol. 66, 15-23, Dec. 2022.
doi:10.1016/j.breast.2022.08.010

12. Jung, Kyung Oh, Hunho Jo, Jung Ho Yu, Sanjiv Sam Gambhir, and Guillem Pratx, "Development and MPI tracking of novel hypoxia-targeted theranostic exosomes," Biomaterials, Vol. 177, 139-148, Sep. 2018.
doi:10.1016/j.biomaterials.2018.05.048

13. Wang, Guorong, Wenzhe Li, Guangyuan Shi, Yu Tian, Lingyan Kong, Ning Ding, Jing Lei, Zhengyu Jin, Jie Tian, and Yang Du, "Sensitive and specific detection of breast cancer lymph node metastasis through dual-modality magnetic particle imaging and fluorescence molecular imaging: A preclinical evaluation," European Journal of Nuclear Medicine and Molecular Imaging, Vol. 49, No. 8, 2723-2734, Jul. 2022.
doi:10.1007/s00259-022-05834-5
Parkins, Katie M., Kierstin P. Melo, Yuanxin Chen, John A. Ronald, and Paula J. Foster, "Visualizing tumour self-homing with magnetic particle imaging," Nanoscale, Vol. 13, 6016-6023, Mar. 2021.
doi:10.1039/d0nr07983a

Dr. Xiaoheng Yan

Mr. Fangtian Liu

Dr. Waldemar Tomasz Smolik

Dr. Xinxian Dan

Dr. Xiaohan Hou