volume | PIER Journals

Abstract

Medical applications of microwaves (i.e. a possibility to use microwave energy and/or microwave technique and technology for therapeutical purposes) are a quite new and very rapidly developing field. Microwave thermotherapy is being used in medicine for cancer treatment and treatment of some other diseases since early eighties. This paper is a contribution to a theory of phase array applicators to be used for a microwave thermotherapy (microwave hyperthermia) in a cancer treatment. It deals with a study and theoretical evaluation of homogeneity of SAR distribution in cylindrical agar phantom for several different values of its radius. Discussed SAR distribution is in our case created by simulations of EM field exposure done by aid of four microwave stripline type TEM mode applicators of the same type.

1. Tahir, F. A., H. Aubert, and E. Girard, "Equivalent electrical circuit for designing MEMS-controlled reflectarray phase shifters," Progress In Electromagnetics Research, Vol. 100, 1-12, 2010.
doi:10.2528/PIER09112506

2. Karim, M. N. A., M. K. A. Rahim, H. A. Majid, O. B. Ayop,M. Abu, and F. Zubir, "Log periodic fractal koch antenna for UHF band applications," Progress In Electromagnetics Research, Vol. 100, 201-218, 2010.
doi:10.2528/PIER09110512

3. Lai, J. C. Y., C. B. Soh, E. Gunawan, and K. S. Low, "Homoge-neous and heterogeneous breast phantoms for ultra-wideband microwave imaging applications," Progress In Electromagnetics Research, Vol. 100, 397-415, 2010.
doi:10.2528/PIER09121103

4. Aliakbarian, H., A. Enayati, G. A. E. Vandenbosch, and W. De Raedt, "Novel low-cost end-wall microstrip-to-waveguide splitter transition," Progress In Electromagnetics Research, Vol. 101, 75-96, 2010.
doi:10.2528/PIER09081805

5. Chang, C., X. Zhu, G. Liu, J. Fang, R. Xiao, C. Chen,H. Shao, J. Li, H. Huang, Q. Zhang, and Z.-Q. Zhang, "Design and experiments of the GW high-power microwave feed horn," Progress In Electromagnetics Research, Vol. 101, 157-171, 2010.
doi:10.2528/PIER10010202

6. Kamarudin, M. R. B., P. S. Hall, F. Colombel, and M. Himdi, "Electronically switched beam disk-loaded monopole array antenna," Progress In Electromagnetics Research, Vol. 101, 339-347, 2010.
doi:10.2528/PIER10010808

7. Dib, N. I., S. K. Goudos, and H. Muhsen, "Application of Taguchi's optimization method and self-adaptive differential evolution to the synthesis of linear antenna arrays," Progress In Electromagnetics Research, Vol. 102, 159-180, 2010.
doi:10.2528/PIER09122306

8. Yang, P., F. Yang, and Z.-P. Nie, "DOA estimation with subarray divided technique and interporlated esprit algorithm on a cylindrical conformal array antenna," Progress In Electromagnetics Research, Vol. 103, 201-216, 2010.
doi:10.2528/PIER10011904

9. O'Halloran, M., M. Glavin, and E. Jones, "Channel-ranked beamformer for the early detection of breast cancer," Progress In Electromagnetics Research, Vol. 103, 153-168, 2010.
doi:10.2528/PIER10030902

10. Conceição, R. C., M. O'Halloran, E. Jones, and M. Glavin, "Investigation of classifiers for early-stage breast cancer based on radar target signatures," Progress In Electromagnetics Research, Vol. 105, 295-311, 2010.
doi:10.2528/PIER10051904

11. O'Halloran, M., M. Glavin, and E. Jones, "Rotating antenna microwave imaging system for breast cancer detection," Progress In Electromagnetics Research, Vol. 107, 203-217, 2010.
doi:10.2528/PIER10071002

12. Gemio, J., J. Parron, and J. Soler, "Human body effects on implantable antennas for ism bands applications: Models comparison and propagation losses study," Progress In Electromagnetics Research, Vol. 110, 437-452, 2010.
doi:10.2528/PIER10102604

13. Mandal, A., H. Zafar, S. Das, and A. V. Vasilakos, "A modified differential evolution algorithm for shaped beam linear array antenna design," Progress In Electromagnetics Research, Vol. 125, 439-457, 2012.
doi:10.2528/PIER11112408

14. Harmer, S. W., S. E. Cole, N. J. Bowring, N. D. Rezgui, and D.Andrews, "On body concealed weapon detection using a phased antenna array," Progress In Electromagnetics Research, Vol. 124, 187-210, 2012.
doi:10.2528/PIER11112105

15. Vrba, J., "Introduction to microwave technology," Faculty of Electrical Engineering CTU in Prague, 2007.

16. Iero, D. A. M., T. Isernia, A. F. Morabito, I. Catapano, and L. Crocco, "Optimal constrained field focusing for hyperthermia cancer therapy: A feasibility assessment on realistic phantoms," Progress In Electromagnetics Research, Vol. 102, 125-141, 2010.
doi:10.2528/PIER10011207

17. García-Jimeno, S., R. Ortega-Palacios, M. Cepeda-Rubio,A. Vera, L. Leija, and J. Estelrich, "Improved thermal ablation effcacy using magnetic nanoparticles: A study in tumor phantoms," Progress In Electromagnetics Research, Vol. 128, 229-248, 2012.

18. Margarethus, M., et al. "A head and neck hyperthermia applicator: Theoretical antenna array design," Int. J. Hyperthermia, Vol. 23, No. 1, 59-67, February 2007.
doi:10.1080/02656730601150522

19. Trujillo-Romero, C. J., S. Garcia-Jimeno, A. Vera, L. Leija, and and J. Estelrich, "Using nanoparticles for enhancing the focusing heating effect of an external waveguide applicator for oncology hyperthermia: Evaluation in muscle and tumor phantoms," Progress In Electromagnetics Research, Vol. 121, 343-363, 2011.
doi:10.2528/PIER11092911

20., IEEE Standard for Safety Levels with Respect to Human Exposure to Radio Frequency Electromagnetic Fields, 3 kHz to 300 GHz, IEEE C95.1-2005, 2005.

21. Kusuma, A. H., A.-F. Sheta, I. Elshafiey, Z. Siddiqui,M. A. S. Alkanhal, S. Aldosari, S. A. Alshebeili, and S. F. Mahmoud, "A new low SAR antenna structure for wireless handset applications," Progress In Electromagnetics Research, Vol. 112, 23-40, 2011.

22. Gelvich, E. A., V. N. Mazokhin, and I. I. Troshin, "An attempt at quantitative specification of SAR distribution homogenity," Int. J.Hyperthermia, Vol. 12, No. 3, 431-436, 1996.
doi:10.3109/02656739609022529

23. Vrba, J., "Medical applications of microwaves," Int J. Hyperthermia, Vol. 24, No. 3, 441-448, 2005.

24. Kantor, G. and T. C. Cetas, "A comparative heating-pattern study of direct-contact applicators in microwave diathermy," Radio Science, Vol. 12, No. 6S, 111-120, 1977.
doi:10.1029/RS012i06Sp00111

25. Falk, M. H. and R. D. Issels, "Hyperthermia in oncology," Int. J.Hyperthermia, Vol. 17, No. 1, 1-18, 2001.
doi:10.1080/02656730150201552

26. Wust, P., et al. "Hyperthermia in cancer treatment: Hyper-thermia in combined treatment of cancer," The Lancet Oncology, Vol. 3, 487-497, 2002.
doi:10.1016/S1470-2045(02)00818-5

27. Simon, C. J., D. E. Dupuy, and W. W. Mayo-Smith, "Microwave ablation: Principles and applications," RadioGraphics, Vol. 25, 69-83, Oct. 2005.
doi:10.1148/rg.25si055501

28. Hoffman, R. M., M. Monga, S. P. Elliot, R. Macdonald, and T. J. Wilt, "Microwave thermotherapy for benign prostatic hyperplasia," Cochrane Database of Systematic Reviews (Online), Oct. 17, 2007.

29. Nikoloski, N., J. Fräohlich, T. Samaras, J. Schuderer, and N. Kuster, "Reevaluation and improved design of the TEM cell in vitro exposure unit for replication studies," Bioelectromagnetics, Vol. 26, 215-224, Apr. 2005.
doi:10.1002/bem.20067

30. Crawford, M. L., "Generation of standard EM fields using TEM transmission cells," IEEE Trans. on Electromagn. Compat., Vol. 16, 189-195, Nov. 1974.

31. Trujillo-Romero, C. J., L. Leija, and A. Vera, "FEM modeling for performance evaluation of an electromagnetic oncology deep hyperthermia applicator when using monopole, inverted T, and plate antennas," Progress In Electromagnetics Research, Vol. 120, 99-125, 2011.

32. Kok, H. P., et al. "The impact of the waveguide aperture size of the 3D 70MHz AMC-8 locoregional hyperthermia system on tumour coverage," Phys. Med. Biol., Vol. 55, 4899-4916, 2010.
doi:10.1088/0031-9155/55/17/002

33. Gellermann, J., et al. "Simulation of different applicator positions for treatment of a presacral tumour," Int. J. Hyperthermia, Vol. 23, No. 1, 37-47, Feb. 2007.
doi:10.1080/02656730601121549

34. Vidal, N., S. Curto, J. M. Lopez-Villegas, J. Sieiro, and F.M. Ramos, "Detuning study of implantable antennas inside the human body," Progress In Electromagnetics Research, Vol. 124, 265-283, 2012.
doi:10.2528/PIER11120515

35. Vrbova, B., "Microwave stripline applicator for local thermotherapy," Diploma thesis, Czech Republic, 2009.

36., Department of Electromagnetical Field in Czech Technical University in Prague, Czech Republic, 2011,Available from http://www.elmag.org..

37. Popovic, M., S. C. Hagness, and A. Taflove, "Finite-difference time-domain analysis of a complete transverse electromagnetic cell loaded with liquid biological media in culture dishes," IEEE Trans. on Biomed. Eng., Vol. 45, 1067-1076, Aug. 1998.
doi:10.1109/10.704876

38. Xiao, S.-Q., Z. Shao, and B.-Z. Wang, "Application of the improved matrix type FDTD method for active antenna analysis," Progress In Electromagnetics Research, Vol. 100, 245-263, 2010.
doi:10.2528/PIER09112204

39. Li, J., L.-X. Guo, and H. Zeng, "FDTD method investigation on the polarimetric scattering from 2-D rough surface," Progress In Electromagnetics Research, Vol. 101, 173-188, 2010.
doi:10.2528/PIER09120104

40. Lee, K. H., I. Ahmed, R. S. M. Goh, E. H. Khoo, E. P. Li, and T. G. G. Hung, "Implementation of the FDTD method based on lorentz-drude dispersive model on gpu for plasmonics applications," Progress In Electromagnetics Research, Vol. 116, 441-456, 2011.

41. Kong, L.-Y., J. Wang, and W.-Y. Yin, "A novel dielectric conformal FDTD method for computing SAR distribution of the human body in a metallic cabin illuminated by an intentional electromagnetic pulse (IEMP)," Progress In Electromagnetics Research, Vol. 126, 355-373, 2012.
doi:10.2528/PIER11112702

Ms. Barbora Vrbova

Prof. Jan Vrba