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PIER PIER B PIER C PIER M PIER Letters
2011-11-01
Using Nanoparticles for Enhancing the Focusing Heating Effect of an External Waveguide Applicator for Oncology Hyperthermia: Evaluation in Muscle and Tumor Phantoms
By
Citlalli Jessica Trujillo-Romero,

    Dr. Citlalli Jessica Trujillo-Romero

    Department of Electrical Engineering

    Cinvestav-IPN

    México

    Homepage

Sonia Garcia-Jimeno,

    Dr. Sonia Garcia-Jimeno

    Departament de Fisicoquímica

    Universitat de Barcelona

    Spain

    Homepage

Arturo Vera-Hernandez,

    Dr. Arturo Vera-Hernandez

    Department of Electrical Engineering

    Cinvestav-IPN

    México

    Homepage

Lorenzo Leija-Salas,

    Dr. Lorenzo Leija-Salas

    Department of Electrical Engineering

    Cinvestav-IPN

    México

    Homepage

Joan Estelrich

    Dr. Joan Estelrich

    Departament de Fisicoquímica

    Universitat de Barcelona

    Spain

    Homepage

Progress In Electromagnetics Research, Vol. 121, 343-363, 2011
doi:10.2528/PIER11092911
Abstract
A technical challenge in hyperthermia therapy is to locally heat the tumor region up to an appropriate temperature to destroy cancerous cells, without damaging the surrounding healthy tissue. Magnetic fluid hyperthermia (MFH) is a novel, minimally invasive therapy aiming at concentrating heat inside cancerous tissues. This therapy is based on the injection of different superparamagnetic nanoparticles inside the tumor. In our study, superparamagnetic nanoparticles, which we developed and characterized, consisted of iron oxide nanoparticles stabilized with polyethylene glycol. Moreover, a new technique for MFH using a specially designed external electromagnetic waveguide as applicator is presented. Three magnetite concentrations were used for making the tumor phantoms, which were embedded in muscle phantoms. The phantoms were radiated and located at three different distances from the applicator. Furthermore, two volumes of tumor (2.5 mL and 5.0 mL) were assayed. Heating curves, as a function of time, allowed the establishment of a more appropriate nanoparticle concentration for obtaining the temperature increase suitable for hyperthermia therapy. The results shown in this paper confirm the feasibility of using nanoparticles as agents to focus the energy over the tumor, without creating hot spots in healthy tissue. In addition, the experiments validated that by using this applicator in combination with nanoparticles, it is also possible to locally control the increments of temperature in tissues.
Citation
Citlalli Jessica Trujillo-Romero, Sonia Garcia-Jimeno, Arturo Vera-Hernandez, Lorenzo Leija-Salas, and Joan Estelrich, "Using Nanoparticles for Enhancing the Focusing Heating Effect of an External Waveguide Applicator for Oncology Hyperthermia: Evaluation in Muscle and Tumor Phantoms," Progress In Electromagnetics Research, Vol. 121, 343-363, 2011.
doi:10.2528/PIER11092911
References

1. Falk, M. H. and R. D. Issels, "Hyperthermia in oncology," International Journal of Hyperthermia, Vol. 17, 1-18, Jan. 2001.
doi:10.1080/02656730150201552

2. Hildebrandt, B., P. Wust, O. Ahlers, et al. "The cellular cellular and molecular basis of hyperthermia," Crit. Rev. Oncology/Hematology, Vol. 43, 33-56, Jul. 2002.
doi:10.1016/S1040-8428(01)00179-2

3. Gupta, R. C. and S. P. Singh, "Elliptically bent slotted waveguide conformal focused array for hyperthermia treatment of tumors in curved region of human body," Progress In Electromagnetics Research, Vol. 62, 107-125, 2006.
doi:10.2528/PIER06012801

4. Gong, Y. and G. Wang, "Superficial tumor hyperthermia with flat left-handed metamaterial lens," Progress In Electromagnetics Research, Vol. 98, 389-405, 2009.
doi:10.2528/PIER09091401

5. Arruebo, M., R. Fernádez-Pacheco, M. R. Ibarra, and J. Santamaría, "Magnetic nanoparticles for drug delivery," Nano Today, Vol. 2, No. 3, 22-32, 2007.
doi:10.1016/S1748-0132(07)70084-1

6. Pankhurst, Q. A., J. Connolly, S. K. Jones, and J. Dobson, "Applications of magnetic nanoparticles in biomedicine," Journal of Physics D: Applied Physics, Vol. 36, No. 13, 167, 2003.
doi:10.1088/0022-3727/36/13/201

7. Babincová, M., P. Cicanec, V. Altanerová, C. Altaner, and P. Babinec, "AC-magnetic field controlled drug release from magnetoliposomes: Design of a method for site-specific chemotherapy," Bioelectrochemistry, Vol. 55, No. 1-2, 17-19, 2002.
doi:10.1016/S1567-5394(01)00171-2

8. Babincová, M., V. Altanerova, C. Altaner, C. Bergemann, and P. Babinec, "In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermia," IEEE Transactions on Nanobioscience, Vol. 7, No. 1, 15-19, 2008.
doi:10.1109/TNB.2008.2000145

9. Luong, T. T., T. P. Ha, L. D. Tran, M. H. Do, T. T. Mai, N. H. Pham, H. B. T. Phan, G. H. T. Pham, N. M. T. Hoang, Q. T. Nguyen, and P. X. Nguyen, "Design of carboxylated fe3o4/poly(styrene-co-acrylic acid) ferrouids with highly efficient magnetic heating effect," Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 384, No. 1-3, 23-30, 2011.
doi:10.1016/j.colsurfa.2011.02.050

10. Hiergeist, R., W. Andra, N. Buske, R. Hergt, I. Hilger, U. Richter, and W. Kaiser, "Application of magnetite ferrouids for hyperthermia," Journal of Magnetism and Magnetic Materials, Vol. 201, 420-422, 1999.
doi:10.1016/S0304-8853(99)00145-6

11. Duguet, E., S. Vasseur, S. Mornet, and J.-M. Devoisselle, "Magnetic nanoparticles and their applications in medicine," Nanomedicine, Vol. 1, No. 2, 157-168, 2006.
doi:10.2217/17435889.1.2.157

12. Thomas, L. A., L. Dekker, M. Kallumadil, P. Southern, M. Wilson, S. P. Nair, Q. A. Pankhurst, and I. P. Parkin, "Carboxylic acid-stabilised iron oxide nanoparticles for use in magnetic hyperthermia," J. Mater. Chem., Vol. 19, 6529-6535, 2009.
doi:10.1039/b908187a

13. Laurent, S., D. Forge, M. Port, A. Roch, C. Robic, L. Vander Elst, and R. N. Muller, "Magnetic iron oxide nanoparticles: Synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications ," Chemical Reviews, Vol. 108, No. 6, 2064-2110, 2008.
doi:10.1021/cr068445e

14. Rovers, S. A., R. Hoogenboom, M. F. Kemmere, and J. T. F. Keurentjes, "Relaxation processes of superparamagnetic iron oxide nanoparticles in liquid and incorporated in poly (methyl methacrylate)," The Journal of Physical Chemistry C, Vol. 112, No. 40, 15643-15646, 2008.
doi:10.1021/jp805631r

15. Ingrid, H., et al. "Magnetic nanoparticles for selective heating of magnetically labelled cells in culture: preliminary investigation ," Nanotechnology, Vol. 15, 1027, 2004.

16. Rudolf, H., et al. "Magnetic particle hyperthermia: Nanoparticle magnetism and materials development for cancer therapy," J. Phys.: Condens. Matter, Vol. 18, 2919, 2006.

17. Wiersma, J. and J. D. V. Dijk, "RF hyperthermia array modelling; validation by means of measured em-field distributions," International Journal of Hyperthermia, Vol. 17, No. 1, 63-81, 2001.
doi:10.1080/02656730150201606

18. Nilsson, P., T. Larsson, and B. Persson, "Absorbed power distributions from two tilted waveguide applicators," International Journal of Hyperthermia, Vol. 1, No. 1, 29-43, 1985.
doi:10.3109/02656738509029272

19. Gardner, R., H. Vargas, J. Block, C. Vogel, A. Fenn, G. Kuehl, and M. Doval, "Focused microwave phased array thermotherapy for primary breast cancer," Annals of Surgical Oncology, Vol. 9, 326-332, 2002.
doi:10.1007/BF02573866

20. Durney, C., C. Johnson, P. Barber, H. Massoudi, M. Iskander, S. Allen, and J. Mitchell, Radiofrequency Radiation Dosimetry Handbook, USAF School of Aerospace Medicine, 1986.

21. Pennes, H. H., "Analysis of skin, muscle and brachial arterial blood temperatures in the resting normal human forearm," Am. J. Med. Sci., Vol. 215, No. 3, 354, 1948.

22. Skumiel, A., A. Jozefczak, M. Timko, P. Kopcansky, F. Herchl, M. Koneracka, and T. N., "Heating effect in biocompatible magnetic fluid," International Journal of Thermophysics, Vol. 28, No. 5, 1461-1469, 2007.
doi:10.1007/s10765-006-0138-y

23. Gabriel, C., Compilation of the dielectric properties of body tissues at RF and microwave frequencies, Report N.AL/OE-TR-1996-0037, Occupational and environmental health directorate, Radiofrequency Radiation Division, Brooks Air Force Base, Texas, USA, Jun. 1996.

24. Iero, D., T. Isernia, A. F. Morabito, I. Catapano, and L. Crocco, "Optimal constrained field focusing for hyperthermia cancer therapy: A feasibility assessment on realistic phantoms," Progress In Electromagnetics Research, Vol. 102, 125-141, 2010.
doi:10.2528/PIER10011207

25. Lai, J. C. Y., C. B. Soh, E. Gunawan, and K. S. Low, "Homogeneous and heterogeneous breast phantoms for ultra-wideband microwave imaging applications," Progress In Electromagnetics Research, Vol. 100, 397-415, 2010.
doi:10.2528/PIER09121103

26. Yoo, D.-S., "The dielectric properties of cancerous tissues in a nude mouse xenograft model ," Bioelectromagnetics, Vol. 25, 492-497, 2004.
doi:10.1002/bem.20021

27. Trujillo-Romero, C. J., L. Leija, and A. Vera, "FEM modeling for performance evaluation of an electromagnetic oncology deep hyperthermia applicator when using monopole, inverted T, and plate antennas," Progress In Electromagnetics Research, Vol. 120, 99-125, 2011.

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