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PIER PIER B PIER C PIER M PIER Letters
2023-04-04
Systemically Delivered, Deep-Tissue Nanoscopic Light Sources
By
Xiang Wu,

    Dr. Xiang Wu

    Department of Materials Science and Engineering

    Stanford University

    USA

    Homepage

Fan Yang,

    Dr. Fan Yang

    Department of Materials Science and Engineering

    Stanford University

    USA

    Homepage

Sa Cai,

    Dr. Sa Cai

    Department of Materials Science and Engineering

    Stanford University

    USA

    Homepage

Guosong Hong

    Dr. Guosong Hong

    Department of Materials Science and Engineering

    Stanford University

    USA

    Homepage

Progress In Electromagnetics Research, Vol. 177, 33-42, 2023
doi:10.2528/PIER22112703
Abstract
Light is widely used in life science in both controlling and observing biological processes, yet a long-standing challenge of using light inside the tissue lies in the limited penetration depth of visible light. In the past decade, many in vivo light delivery methods using photonics and materials science tools have been developed, with recent demonstrations of non-invasive, deep-tissue light sources based on systemically delivered luminescent nanomaterials. In this perspective, we provide an overview for the principles of intravital nanoscopic light sources and discuss their advantages over existing methods for in vivo light delivery. We then highlight their recent applications in optogenetics neuromodulation and fluorescent imaging in live animals. We also present an outlook section about the feasibility of combining these non-invasive light sources with other modalities to expand the utilities of light in biology.
Citation
Xiang Wu, Fan Yang, Sa Cai, and Guosong Hong, "Systemically Delivered, Deep-Tissue Nanoscopic Light Sources," Progress In Electromagnetics Research, Vol. 177, 33-42, 2023.
doi:10.2528/PIER22112703
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