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PIER PIER B PIER C PIER M PIER Letters
2015-01-12
A Study on the Biocompatibility of Surface-Modified Au/Ag Alloyed Nanobox Particles in Zebrafish in Terms of Mortality Rate, Hatch Rate and Imaging of Particle Distribution Behavior
By
Kanghui Li,

    Dr. Kanghui Li

    Centre for Optical and Electromagnetic Research

    Zhejiang University

    China

    Homepage

Xinyuan Zhao,

    Dr. Xinyuan Zhao

    School of Medicine

    Zhejiang University

    China

    Homepage

Yixing Zhai,

    Dr. Yixing Zhai

    School of Medicine

    Zhejiang University

    China

    Homepage

Guangdi Chen,

    Dr. Guangdi Chen

    School of Medicine

    Zhejiang University

    China

    Homepage

El-Hang Lee,

    Dr. El-Hang Lee

    Graduate School of Information Technology and Telecommunication

    INHA University

    South Korea

    Homepage

Sailing He

    Prof. Sailing He

    Department of Electromagnetic Theory

    Royal Institute of Technology

    Sweden

    Homepage

Progress In Electromagnetics Research, Vol. 150, 89-96, 2015
doi:10.2528/PIER14092602
Abstract
We report, for the first time, a study on the biocompatibility of the poly(ethylene glycol)-thiol (PEG)-coated Au/Ag alloyed nanobox (PC-ANB) particles in zebrafish. We measured the mortality rate and the hatch rate of the zebrafish embryos injected with the PC-ANB particles and observed the distribution of the PC-ANB particles in the zebrafish embryos at different stages of growth development. The results show that the PC-ANB particles have negligible toxicity to the zebrafish embryos even at extra-high concentration (1.2 mg ml-1), while uncoated Ag nanoparticles, used in the form of nanospheres or nanoplates, were found to cause embryo deformation or even death. Additionally, we have investigated the distribution of the PC-ANB particles within the zebrafish in the interest of studying their behavior in the zebrafish using imaging. For this, we used the three-photon luminescence imaging technique and it has been found that the PC-ANB particles mainly assemble in the backside muscle tissues of the zebrafish, suggesting that the PC-ANB particles are mostly metabolized out after about 96 hours of growth development.
Citation
Kanghui Li, Xinyuan Zhao, Yixing Zhai, Guangdi Chen, El-Hang Lee, and Sailing He, "A Study on the Biocompatibility of Surface-Modified Au/Ag Alloyed Nanobox Particles in Zebrafish in Terms of Mortality Rate, Hatch Rate and Imaging of Particle Distribution Behavior," Progress In Electromagnetics Research, Vol. 150, 89-96, 2015.
doi:10.2528/PIER14092602
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