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PIER PIER B PIER C PIER M PIER Letters
2011-10-15
Integrated Waveguide Structure for Highly Sensitive THz Spectroscopy of Nano-Liter Liquids in Capillary Tubes
By
Vladimir Matvejev,

    Dr. Vladimir Matvejev

    Department of Electronics and Informatics

    Vrije Universiteit Brussel

    Belgium

    Homepage

Cathleen De Tandt,

    Dr. Cathleen De Tandt

    Vrije Universiteit Brussel (VUB)

    Belgium

    Homepage

Willy Ranson,

    Dr. Willy Ranson

    Vrije Universiteit Brussel (VUB)

    Belgium

    Homepage

Johan Stiens,

    Dr. Johan Stiens

    ETRO-TW

    Vrije Universiteit Brussel (VUB)

    Belgium

    Homepage

Roger Vounckx,

    Dr. Roger Vounckx

    Vrije Universiteit Brussel

    Belgium

    Homepage

Debby Mangelings

    Dr. Debby Mangelings

    Vrije Universiteit Brussel (VUB)

    Belgium

    Homepage

Progress In Electromagnetics Research, Vol. 121, 89-101, 2011
doi:10.2528/PIER11090102
Abstract
Terahertz dielectric spectroscopy permits the study of biomolecular interactions. However, water induces high attenuation of electromagnetic waves in the THz frequency range, obscuring the response of biomolecules. The developed sensor overcomes this problem by concentrating the THz wave propagating in an integrated waveguide on a small liquid volume contained within a capillary tube. Detailed electromagnetic modeling shows effective interaction between the THz waves and liquids. Transmission measurement results for capillary tubes filled with water and methanol mixtures demonstrate a substantial increase in sensitivity to changes of liquid permittivity. The current integrated sensor facilitates THz spectroscopy of biological liquids: a case study on buffered human serum albumin solution demonstrates a great potential to complement biochemical analytical tools.
Citation
Vladimir Matvejev, Cathleen De Tandt, Willy Ranson, Johan Stiens, Roger Vounckx, and Debby Mangelings, "Integrated Waveguide Structure for Highly Sensitive THz Spectroscopy of Nano-Liter Liquids in Capillary Tubes," Progress In Electromagnetics Research, Vol. 121, 89-101, 2011.
doi:10.2528/PIER11090102
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