volume | PIER Journals

Abstract

The essential cause of Multiple Sclerosis (MS) remains to be unknown until present. Although the relevance of racial, genetic, immunological and environmental causal factors has been accepted and expressed by various researchers, there has not been an elaborate study as to the essential cause of MS. This study aims to explain the importance of the environmental causal factor on the occurrence of MS compared to the racial, immunological and genetic factors. In this study, especially the Extreme Low Frequency (ELF) electromagnetic fields and electromagnetic fields at a frequency band (10⁹-10¹³) Hz in terms of dielectrophoretic effect on myelin in dispersive gray matter and white matter are regarded as the essential causal factor of MS regardless of the fact, whether their sources are artificial or natural. There are epidemiological and experiment-based studies that support this view. In order to support my view, I made use of several comparative studies and obtained computational data. Dielectrophoretic force in the human body, especially in gray and white matter can affect on the myelin basic proteins and be the cause of accumulating them.

1. Bates, I. R., J. B. Feix, J. M. Boggs, and G. Harauz, "An immunodominant epitope of myelin basic protein is an amphipathic α-helix," J. Biol. Chem., Vol. 279, No. 7, 5757-5764, 2004.
doi:10.1074/jbc.M311504200

2. Ramagopalan, S. V., R. McMahon, D. A. Dyment, A. D. Sadovnick, G. C. Ebers, and K. M. Wittkowski, "An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRBI gene," BMC Med. Genet., Vol. 10, No. 10, 2009.

3. Sadovnick, A. D. and G. C. Ebers, "Genetics of multiple sclerosis," J. Biol. Chem., Vol. 13, 99-108, 1995.

4. Compston, A., "The genetics of multiple sclerosis," J. Neurovir., Vol. 6, No. 2, 55-59, 2000.

5. Martyn, C., "The epidemiology of multiple sclerosis," McAlpine's Multiple Sclerosis, 3rd edition, W. B. Matthews (ed.), Churchill Livingstone, 1991.

6. Doerksen, S. E., R. W. Motl, and E. McAuley, "Environmental correlates of physical activity in multiple sclerosis: A cross-sectional study," Inter. J. Behav. Nutr. Physic. Act., Vol. 4, No. 49, 2007.

7. Schwarz, S. and H. Leweling, "Multiple sclerosis and nutrition," Mult. Scler., Vol. 11, No. 1, 24-32, 2005.
doi:10.1191/1352458505ms1119oa

8. Simmons, R. D., A-L. Ponsonby, I. A. F. van der Mei, and P. Sheridan, "What affects your MS? Responses to an anonymous, internet-based epidemiological survey," Mult. Scler., Vol. 10, No. 2, 202-211, 2004.
doi:10.1191/1352458504ms1006oa

9. Beniac, D. R., M. D. Luckevich, G. J. Czarnota, T. A. Tompkins, R. A. Ridsdale, F. Ottensmeyer, M. A. Moscarello, and G. Harauz, "Three-dimensional structure of myelin basic protein," J. Bio. Chem., Vol. 272, 4261-4268, 1997.

10. Stankoff, B., Y. Wang, M. Bottlaender, M. Aigrot, S. Aigrot, and F. Dolle, "Imaging of CNS myelin by positron emission tomography," Proc. Natl. Acad. Sci., Vol. 103, No. 24, 9304-9309, 2006.

11. Noseworthy, J. H., C. Lucchinetti, M. Rodriguez, and B. G. Weinshenker, "Multiple sclerosis," N. Engl. J. Med., Vol. 343, No. 13, 938-952, 2000.
doi:10.1056/NEJM200009283431307

12., ``MS Atlas," WHO, 2008.

13. Abidin, Z. Z., A. G. L. Abdullah, Z. Yunus, and G. H. Markx, "Wire cloth electrodes: A study of electric field for dielectrophoretic separation of cells," I. J. Eng. Tech., Vol. 4, No. 2, 205-212, 2007.

14. Hu, Y., I. Doudevski, D. Wood, M. Moscarello, C. Husted, C. Genain, J. A. Zasadzinski, and J. Israelachvili, "Synergistic interactions of lipids and myelin basic protein," Proc. Natl. Acad. Sci., Vol. 101, No. 37, 13466-13471, 2004.

15. Jones, T. B., "Dielectrophoretic force calculation," J. Electrostat., Vol. 6, 69-82, 1995.

16. Foster, K. R. and H. P. Schwan, "Dielectric properties of tissues and biological materials: A critical review," Crit. Rev. Biomed. Eng., Vol. 17, No. 1, 25-104, 1989.

17. Gabriel, C., S. Gabriel, and E. Cortout, "The dielectric properties of biological tissues: I. Literature survey," Phys. Med. Bio., Vol. 41, No. 11, 2231-2249, 1996.
doi:10.1088/0031-9155/41/11/001

18. Gabriel, S., R. W. Lau, and C. Gabriel, "The dielectric properties of biological tissues: II. Measurements of the frequency range 10 Hz to 20 GHz," Phys. Med. Bio., Vol. 41, No. 11, 2251-2269, 1996.
doi:10.1088/0031-9155/41/11/002

19. Gabriel, S., R. W. Lau, and C. Gabriel, "The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues," Phys. Med. Bio., Vol. 41, No. 11, 2271-2293, 1996.
doi:10.1088/0031-9155/41/11/003

20. Bindu, G., A. Lonappan, V. Thomas, C. K. Aanandan, and K. T. Mathew, "Dielectric studies of corn syrup for applications in microwave breast imaging," Progress In Electromagnetics Research, Vol. 59, 175-186, 2006.
doi:10.2528/PIER05072801

21. Kumar, A., S. Sharma, and G. Singh, "Measurement of dielectric constant and loss factor of the dielectric material at microwave frequencies," Progress In Electromagnetics Research, Vol. 69, 47-54, 2007.
doi:10.2528/PIER06111204

22. Yan, L., K. Huang, and C. Liu, "A noninvasive method for determining dielectric properties of layered tissues on human back," Journal of Electromagnetic Waves and Applications, Vol. 21, No. 13, 1829-1843, 2007.

23. Challa, R. K., D. Kajfez, J. R. Gladden, A. Z. Elsherbeni, and V. Demir, "Permittivity measurement with a non-standard waveguide by using TRL calibration and fractional linear data fitting," Progress In Electromagnetics Research B, Vol. 2, 1-13, 2008.
doi:10.2528/PIERB07102001

24. Canbay, C. and I. Unal, "Electromagnetic modeling of retinal photoreceptors," Progress In Electromagnetics Research, Vol. 83, 353-374, 2008.
doi:10.2528/PIER08062004

25. Zhang, H., S. Y. Tan, and H. S. Tan, "A novel method for microwave breast cancer detection," Progress In Electromagnetics Research, Vol. 83, 413-434, 2008.
doi:10.2528/PIER08062701

26. Wang, Z., W. Che, and L. Zhou, "Uncertainty analysis of the rational function model used in the complex permittivity measurement of biological tissues using PMCT probes within a wide microwave frequency band," Progress In Electromagnetics Research, Vol. 90, 137-150, 2009.
doi:10.2528/PIER09010403

27. Sardeshpande, S. and A. Chatterjee, "Electromagnetic wave propagation in linearly dispersive media using higher-order WENO scheme," Journal of Electromagnetic Waves and Applications, Vol. 23, No. 16, 2135-2142, 2009.
doi:10.1163/156939309790109270

28. Chen, K. M., H. R. Chuang, and C. J. Lin, "Quantification of interaction between ELF-LF electric fields and human bodies," IEEE Trans. Biomed. Eng., Vol. 33, No. 8, 746-756, 1986.
doi:10.1109/TBME.1986.325898

29. Kaune, W. T. and W. C. Forsythe, "Current densities measured in human models exposed to 60 Hz electric fields," Bioelectromagnetics, Vol. 6, No. 1, 13-32, 1985.
doi:10.1002/bem.2250060103

30. Schlegel, K. and K. M. Fullekrug, "50 years of Schumann Resonance," Physik in Unserer Zeit, Vol. 33, No. 6, 256-264, 2002.
doi:10.1002/1521-3943(200211)33:6<256::AID-PIUZ256>3.0.CO;2-V

31. Rakov, V. A. and M. A. Uman, Lightning: Physics and Effects, Cambridge Univ. Press, 2003.

32. Song, T.-X., Y.-H. Liu, and J.-M. Xiong, "Computations of electromagnetic fields radiated from complex lightning channels," Progress In Electromagnetics Research, Vol. 73, 93-105, 2007.
doi:10.2528/PIER07032501

33. Baginski, M. E., "Finite element solution of the atmosphere's electromagnetic response to charge perturbations associated with lightning," Progress In Electromagnetics Research, Vol. 8, 299-348, 1994.

34. Substations Committee of the IEEE Power Engineering Society "IEEE guide for direct lightning stroke shielding of substations," IEEE Std 998-1996, i-163, 1996.

35. Pulinets, S., G. Bisiacchi, J. Berlinski, M. Dunajecka, and A. Vega, "First results of the new type of measurements of atmospheric electric field in Mexico," Bol-e, Vol. 2, No. 6, 2006.

36. Manapati, M. B. and R. S. Kshetrimayum, "SAR reduction in human head from mobile phone radiation using single negative metamaterials," Journal of Electromagnetic Waves and Applications, Vol. 23, No. 10, 1385-1395, 2009.
doi:10.1163/156939309789108606

37. Mohsin, S. A. and N. M. Sheikh, "MRI induced heating of deep brain stimulation leads: Effect of the air-tissue interface," Progress In Electromagnetics Research, Vol. 83, 81-91, 2008.
doi:10.2528/PIER08040504

Dr. Cahit Canbay