Vol. 142

Front:[PDF file] Back:[PDF file]
Latest Volume
All Volumes
All Issues

Vectorial Electric Field Monte Caro Simulations for Focused Laser Beams (800 Nm -2220 Nm ) in a Biological Sample

By Fuhong Cai, Jiaxin Yu, and Sailing He
Progress In Electromagnetics Research, Vol. 142, 667-681, 2013


Here we develop a method that combines vectorial electric field Monte Carlo simulation with Huygens-Fresnel principle theory to determine the intensity distribution of a focused laser beam in a biological sample. The proper wavelengths for deep tissue imaging can be determined by utilizing our method. Furthermore, effects of anisotropic factor, scattering and absorption coefficients on the focal spots are analyzed. Finally, the focal beams formed by objective lenses with different values of numerical aperture are also simulated to study the focal intensity in the biological sample.


Fuhong Cai, Jiaxin Yu, and Sailing He, "Vectorial Electric Field Monte Caro Simulations for Focused Laser Beams (800 Nm -2220 Nm ) in a Biological Sample," Progress In Electromagnetics Research, Vol. 142, 667-681, 2013.


    1. Boas, D. A., D. H. Brooks, E. L. Miller, C. A. Dimarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, "Imaging the body with diffuse optical tomography," IEEE Signal Process Mag., Vol. 18, No. 6, 57-75, 2001.

    2. Karanasiou, I. S., N. K. Uzunoglu, and A. Garetsos, "Electromagnetic analysis of a non-invasive 3D passive microwave imaging system," Progress In Electromagnetics Research, Vol. 44, 287-308, 2004.

    3. Goharian, M., M. Soleimani, and G. R. Moran, "A trust region subproblem for 3D electrical impedance tomography inverse problem using experimental data," Progress In Electromagnetics Research, Vol. 94, 19-32, 2009.

    4. Yodh, A. and B. Chance, "Spectroscopy and imaging with diffusing light," Phys. Today, Vol. 48, 34-40, 1995.

    5. Kobat, D., M. E. Durst, N. Nishimura, A. W. Wong, C. B. Schaffer, and C. Xu, "Deep tissue multiphoton microscopy using longer wavelength excitation," Opt. Express, Vol. 17, No. 16, 13354-13364, 2009.

    6. Horton, N. G., K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, "In vivo three-photon microscopy of subcortical structures within an intact mouse brain," Nature Photonics, Vol. 7, 205-209, 2013.

    7. Wang, P., H.-W. Wang, M. Sturek, and J.-X. Cheng, "Bond-selective imaging of deep tissue through the optical window between 1600 and 1850 nm," J. Biophotonics, Vol. 5, No. 1, 25-32, 2012.

    8. Wang, L., S. L. Jacques, and L. Zheng, "MCML---Monte Carlo modeling of light transport in multi-layered tissues," Computer Methods and Programs in Biomedicine, Vol. 47, No. 2, 141-146, 1995.

    9. Guo, Z., F. Cai, and S. He, "Optimization for brain activity monitoring with near infrared light in a four-layered model of the human head," Progress In Electromagnetics Research, Vol. 140, 277-295, 2013.

    10. Pawley, J. B., "Handbook of Biological Confocal Microscopy," Springer, 2006.

    11. Xu, M., "Electric field Monte Carlo simulation of polarized light propagation in turbid media," Opt. Express, Vol. 12, No. 26, 6530-6539, 2004.

    12. Hayakawa, C. K., V. Venugopalan, V. V. Krishnamachari, and E. O. Potma, "Amplitude and phase of tightly focused laser beams in turbid media," Phys. Rev. Lett., Vol. 103, 043903, 2009.

    13. Hayakawa, C. K., E. O. Potma, and V. Venugopalan, "Electric field Monte Carlo simulations of focal field distributions produced by tightly focused laser beams in tissues," Biomed. Opt. Express, Vol. 2, No. 2, 278-299, 2011.

    14. Wang, Y., P. Li, C. Jiang, J.Wang, and Q. Luo, "GPU accelerated electric field Monte Carlo simulation of light propagation in turbid media using a finite-size beam model," Opt. Express, Vol. 20, No. 15, 16618-16630, 2012.

    15. Li, M., P. Lu, Z. Yu, L. Yan, Z. Chen, C. Yang, and X. Luo, "Vector Monte Carlo simulations on atmospheric scattering of polarization qubits," J. Opt. Soc. Am. A, Vol. 30, 448-454, 2013.

    16. Hale, G. M. and M. R. Querry, "Optical constants of water in the 200-nm to 200-\mu m wavelength region," Appl. Opt., Vol. 12, No. 3, 555-563, 1973.

    17., .

    18. Ding, H., J. Q. Lu, W. A. Wooden, P. J. Kragel, and X.-H. Hu, "Refractive indices of human skin tissues at eight wavelengths and estimated dispersion relations between 300 and 1600 nm," Phys. Med. Biol., Vol. 51, No. 6, 1479-1489, 2006.

    19. Xu, X. and W. W. Webb, "Measurement of two-photon excitation cross sections of molecular fluorophores with data from 690 to 1050 nm," JOSA B, Vol. 13, No. 3, 481-491, 1996.

    20. Song, Y. J., M. L. Hu, C. L. Wang, Z. Tian, Q. R. Xing, L. Chai, and C. Y. Wang, "Environmentally stable, high pulse energy Yb-doped large-mode-area photonic crystal fiber laser operating in the soliton-like regime," IEEE Photonics Technology Letters, Vol. 20, No. 13, 1088-1090, 2008.

    21. Wang, Y. M., B. Judkewitz, C. A. DiMarzio, and C. Yang, "Deep-tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light," Nature Communications, Vol. 3, 928, 2012.