Vol. 128

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Improved Thermal Ablation Efficacy Using Magnetic Nanoparticles: a Study in Tumor Phantoms

By Sonia García-Jimeno, Rocío Ortega-Palacios, Mario Francisco Cepeda-Rubio, Arturo Vera, Lorenzo Leija-Salas, and Joan Estelrich
Progress In Electromagnetics Research, Vol. 128, 229-248, 2012


Magnetic heating used for inducing hyperthermia and thermal ablation is particularly promising in the treatment of cancer provided that the therapeutic temperature is kept constant during the treatment time throughout the targeted tissue and the healthy surrounding tissues are maintained at a safe temperature. The present study shows the temperature increment produced by different concentrations of magnetic nanoparticles (ferrofluid and magnetoliposomes) inside a phantom, after irradiating tissue-mimicking materials (phantoms) with a minimally invasive coaxial antenna working at a frequency of 2.45 GHz. This frequency was chosen because maximum dielectric loss of water molecules begins at 2.4 GHz and because this is an ISM (industrial, scientific and medical) frequency. Temperature sensors were placed inside and outside the tumor phantom to assess the focusing effect of heat produced by nanoparticles. Results have shown that the temperature increments depend on the nanoparticles concentration. In this way, a temperature increment of more than 56 ºC was obtained with a ferrofluid concentration of 13.2 mg/mL, whereas the increment in the reference phantom was only of ≈ 21 ºC. Concerning the magnetoliposomes, the temperature achieved was similar to that obtained with the ferrofluid but at a lesser concentration of nanoparticles. These results demonstrate that it is possible to achieve higher temperatures and to focus energy where the nanoparticles are located.


Sonia García-Jimeno, Rocío Ortega-Palacios, Mario Francisco Cepeda-Rubio, Arturo Vera, Lorenzo Leija-Salas, and Joan Estelrich, "Improved Thermal Ablation Efficacy Using Magnetic Nanoparticles: a Study in Tumor Phantoms," Progress In Electromagnetics Research, Vol. 128, 229-248, 2012.


    1. Miltenyi, S., W. Muller, W. Weichel, and A. Radbruch, "High gradient magnetic cell separation with MACS," Cytometry, Vol. 11, 231-238, 1990.

    2. Radbruch, A., B. Mechtold, A. Thiel, S. Miltenyi, and E. Pfluger, "High-gradient magnetic cell sorting," Methods in Cellular Biology, Vol. 42, 387-403, 1994.

    3. Safarik, I. and M. Safarikova, "Use of magnetic techniques for the isolation of cells," Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 722, 33-53, 1999.

    4. Swan, H., Thermoregulation and Bioenergetics, Elsevier, Amsterdam,1974.

    5. Suit, H. and M. Shwayder, "Hyperthermia: Potential as an antitumour agent," Cancer, Vol. 34, 122-129, 1974.

    6. Hahn, G., Hyperthermia and Cancer, Plenum Press, New York,1982.

    7. Kettering, M., J. Winter, M. Zeisberger, S. Bremer-Streck,H. Oehring, C. Bergemann, C. Alexiou, R. Hergt, K. J. Halbhuber,W. A. Kaiser, and I.Hilger, "Magnetic nanoparticles as bimodal tools in magnetically induced labeling and magnetic heating of tumour cells: An in vitro study," Nanotechnology, Vol. 18, 175101,2007.

    8. Simon, C. J., D. E. Dupuy, and W. W. Mayo-Smith, "Microwave ablation: Principles and applications," Radio Graphics, Vol. 25, S69-S83, 2005.

    9. Safarik, I. and M. Safarikova, "Magnetic nanoparticles in biosciences," Monatschefte für Chemie, Vol. 133, 737-759, 2002.

    10. Saiyed, Z. M., S. D. Telang, and C. N. Ramchand, "Application of magnetic techniques in the field of drug discovery and biomedicine," BioMagnetic Research and Technology, Vol. 1, 2,2003.

    11. Diederich, C. J., "Thermal ablation and high-temperature thermal therapy: Overview of technology and clinical implementation," International Journal of Hyperthermia, Vol. 21, 745-753, 2005.

    12. Oura, S., T. Tamaki, I. Hirai, T. Yoshimasu, F. Ohta,R. Nakamura, and Y. Okamura, "Radiofrequency ablation therapy in patients with breast cancers two centimeters or less in size," Breast Cancer, Vol. 14, 48-54, 2007.

    13. Rosensweig, R. E., "Heating magnetic fluid with alternating magnetic field," Journal of Magnetism and Magnetic Materials, Vol. 252, 370-374, 2002.

    14. Rovers, S. A., R. Hoogenbomm, M. F. Kemmere, and J. T. F. Keurentjes, "Relaxation processes of superparamagnetic iron oxide nanoparticles in liquid and incorporated in poly (methyl methacrylate)," Journal of Physical Chemistry C, Vol. 112, 15643-15646, 2008.

    15. Pankurst, Q. A., J. Connolly, S. K. Jones, and J. Dobson, "Applications of magnetic nanoparticles in biomedicine," Journal of Physics D: Applied Physics, Vol. 36, R167-R181, 2003.

    16. Huang, H., F. H. Xue, B. Lu, F. Wang, X. L. Dong, and W. J. Park, "Enhanced polarization in tadpole-shaped (Ni, Al)/Aln nanoparticles and microwave absorption at high frequencies," Progress In Electromagnetics Research B, Vol. 34, 31-46, 2011.

    17. Hergt, R. and W. Andrä, "Magnetic hyperthermia and thermoablation," Magnetism in Medicine, 2nd Edition, W. Andrä and H. Nowak, editor, Wiley-VCH, Berlin,2007.

    18. Lai, J. C. Y., C. B. Soh, E. Gunawan, and K. S. Low, "Homogeneous and hetero-geneous breast phantoms for ultra-wideband microwave imaging applications," Progress In Electromagnetics Research, Vol. 100, 397-415, 2010.

    19. Sabaté, R, R. Barnadas-Rodrguez, J. Callejas-Fernández,R. Hidalgo-Ālvarez, and J. Estelrich, "Preparation and characterization of extruded magnetoliposomes," International Journal of Pharmaceutics, Vol. 347, 156-162, 2008.

    20. Cepeda, M. F. J., A. Vera. and L. Leija, "Coaxial antenna for microwave coagulation therapy in ex vivo swine breast tissue," 7th International Conference on Electrical Engineering, Computing Science and Automatic Control (CCE 2010), 8-10, Tuxtla Gutiérrez,Chiapas, México, Sept.2010.

    21. Trujillo-Romero, C. J., S. García-Jimeno, A. Vera, L. Leija,and J. Estelrich, "Using nanoparticles for enhancing the focusing heating effect of an external waveguide applicator for oncology hyperthermia: Evaluation in muscle and tumor phantoms," Progress In Electromagnetics Research, Vol. 121, 343-363, 2011.

    22. Lazebnik, F. M., et al., "A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries," Physics in Medicine and Biology, Vol. 52, 6093-6115, 2007.

    23. Guy, A. W., "Analysis of electromagnetic fields induced in biological tissues by thermographic studies on equivalent phantom models," IEEE Transactions in Microwave Theory and Techniques, Vol. 19, 205-214, 1971.

    24. Leslie-Peleckie, D. L. and R. D. Rieke, "Magnetic properties of nanostructured materials," Chemistry of Materials, Vol. 8, 1770-1783, 1996.

    25. Iero, D., T. Isernia, A. F. Morabito, I. Catapano, and L. Crocco, "Optimal constrained field focusing for hyperthermia cancer therapy: A feasibility assessment on realistic phantoms," Progress In Electromagnetics Research, Vol. 102, 125-141, 2010.

    26. Keblinski, P., S. R. Phillpot, S. U. S. Choi, and J. A. Eastman, "Mechanisms of heat flow in suspensions of nano-sized particles (nanofluids)," International Journal of Heat and Mass Transfer, Vol. 45, 855-863, 2002.

    27. Gemio, J., J. Parrón, and J. Soler, "Human body effects on implantable antennas for ISM bands applications: Models comparison and propagation losses study," Progress In Electromagnetics Research, Vol. 110, 437-452, 2010.